The E4OD was updated in 1998 and this new transmission was the last rendition of the C6. It was largely the same as the E40D, but with some changes to internal components to address durability concerns when put behind the ever increasingly powerful Powerstroke Diesel Engine. In 1999 it was fitted with a PTO for auxiliary equipment attached to heavy duty trucks. To follow Fords new naming schemes for its other transmissions, Ford renamed the E4OD the 4R100.
1999–2004 Ford Lightning (F-150 SVT)
2002–2003 Ford F-150 Harley-Davidson Edition
1999–2003 Ford Super Duty
1999–2003 Ford Expedition (with 5.4 V-8)
2000–2003 Ford Excursion
1997–2004 Ford E-Series